abstract：PURPOSE:To evaluate the development of demographics and outcome of very old (>80 years) critically ill patients admitted to intensive care units. SETTING:All consecutive patients admitted to 41 Austrian intensive care units (ICUs) over an 11-year period. METHODS:We performed a retrospective cohort study of prospectiv...

journal_title：Intensive care medicine

authors： Ihra GC,Lehberger J,Hochrieser H,Bauer P,Schmutz R,Metnitz B,Metnitz PG

更新日期：2012-04-01 00:00:00

abstract：OBJECTIVE:The Pediatric Index of Mortality 2 (PIM2), one of the key mortality prediction models for children in intensive care units, has not been validated in Japan. The purpose of this study was to validate the performance of PIM2 in a population of patients admitted to one pediatric intensive care unit (PICU) in Jap...

journal_title：Intensive care medicine

authors： Imamura T,Nakagawa S,Goldman RD,Fujiwara T

更新日期：2012-04-01 00:00:00

abstract：PURPOSE:In critically ill pediatric patients, fluid overload (FO) >10% has been identified as a threshold for possible interventions, including initiation of continuous renal replacement therapy (CRRT). However, multiple definitions have been reported, and there remains no consensus method for FO calculation. The goal ...

journal_title：Intensive care medicine

authors： Lombel RM,Kommareddi M,Mottes T,Selewski DT,Han YY,Gipson DS,Collins KL,Heung M

更新日期：2012-04-01 00:00:00

abstract：PURPOSE:To describe changes in hemodynamic variables, sedation, and pain score after discontinuation of prolonged infusions of dexmedetomidine in a pediatric population of critically ill cardiac patients. METHODS:Retrospective case series of patients who received continuous infusions of dexmedetomidine for longer than...

journal_title：Intensive care medicine

authors： Burbano NH,Otero AV,Berry DE,Orr RA,Munoz RA

更新日期：2012-02-01 00:00:00

abstract：PURPOSE:The aim of our study was to explore, using an innovative method, the effect of temporal changes in the mortality prediction performance of an existing model on the quality of care assessment. The prognostic model (rSAPS-II) was a recalibrated Simplified Acute Physiology Score-II model developed for very elderly...

journal_title：Intensive care medicine

authors： Minne L,Eslami S,de Keizer N,de Jonge E,de Rooij SE,Abu-Hanna A

更新日期：2012-01-01 00:00:00

abstract：PURPOSE:Extracorporeal life support (ECLS) is used for patients with refractory heart failure with or without respiratory failure. This temporary support is provided by blood pumps which are connected to large vessels. Bleeding episodes are a typical complication in patients with ECLS. Recently, several studies illustr...

journal_title：Intensive care medicine

authors： Heilmann C,Geisen U,Beyersdorf F,Nakamura L,Benk C,Trummer G,Berchtold-Herz M,Schlensak C,Zieger B

更新日期：2012-01-01 00:00:00

abstract：PURPOSE:Because non-invasive mechanical ventilation (NIV) is increasingly used, new devices, both ventilators and interfaces, have been continuously proposed for clinical use in recent years. To provide the clinicians with valuable information about ventilators and interfaces for NIV, several bench studies evaluating a...

journal_title：Intensive care medicine

authors： Olivieri C,Costa R,Conti G,Navalesi P

更新日期：2012-01-01 00:00:00

abstract：OBJECTIVE:To examine the benefits and risks of vasopressin or its analog terlipressin for patients with vasodilatory shock. DATA SOURCE:We searched the CENTRAL, MEDLINE, EMBASE, and LILACS databases (up to March 2011) as well as reference lists of articles and proceedings of major meetings; we also contacted trial aut...

journal_title：Intensive care medicine

authors： Polito A,Parisini E,Ricci Z,Picardo S,Annane D

更新日期：2012-01-01 00:00:00

abstract：PURPOSE:To test the hypothesis that RNA editing is altered in pediatric patients with cyanotic congenital heart disease (CHD) and to determine whether A-to-I RNA editing is associated with the postoperative course following cardiac surgery. Cyanotic CHD is associated with a unique pathophysiology caused by chronic hypo...

journal_title：Intensive care medicine

authors： Borik S,Simon AJ,Nevo-Caspi Y,Mishali D,Amariglio N,Rechavi G,Paret G

更新日期：2011-10-01 00:00:00

abstract：PURPOSE:We conducted a retrospective cohort study in an academic tertiary care center to characterize ventilator-associated pneumonia (VAP) in pediatric patients after cardiac surgery in The Netherlands. METHODS:All patients following cardiac surgery and mechanically ventilated for ≥24 h were included. The primary out...

journal_title：Intensive care medicine

authors： Roeleveld PP,Guijt D,Kuijper EJ,Hazekamp MG,de Wilde RB,de Jonge E

更新日期：2011-10-01 00:00:00

abstract：PURPOSE:We evaluated the impact of increasing tidal volume (V (t)), decreased chest wall compliance, and left ventricular (LV) contractility during intermittent positive-pressure ventilation (IPPV) on the relation between pulse pressure (PP) and LV stroke volume (SV(LV)) variation (PPV and SVV, respectively), and intra...

journal_title：Intensive care medicine

authors： Mesquida J,Kim HK,Pinsky MR

更新日期：2011-10-01 00:00:00

abstract：PURPOSE:The aim of our study was to analyze changes in the consumption of MRSA-active antibiotics and in the burden of methicillin-resistant S. aureus (MRSA) over a period of 9 years in a network of German intensive care units (ICU). METHODS:Data from 55 ICUs in Germany were analyzed from 2001 through 2009. The term "...

journal_title：Intensive care medicine

authors： Meyer E,Schwab F,Schroeren-Boersch B,Gastmeier P

更新日期：2011-10-01 00:00:00

abstract：PURPOSE:Septic shock induces a decrease in dendritic cells (DCs) that may contribute to sepsis-induced immunosuppression. We analyzed the time course of circulating DCs in patients with septic shock and its relation to susceptibility to intensive care unit (ICU)-acquired infections. METHODS:We enrolled adult patients ...

journal_title：Intensive care medicine

authors： Grimaldi D,Louis S,Pène F,Sirgo G,Rousseau C,Claessens YE,Vimeux L,Cariou A,Mira JP,Hosmalin A,Chiche JD

更新日期：2011-09-01 00:00:00

abstract：PURPOSE:To compare the concentration conformity of infusion solutions manually prepared on intensive care units (ICU) with solutions from pharmacy-based, automated production. METHODS:A prospective observational study conducted in a university hospital in Germany. Drug concentrations of 100 standardised infusion solut...

journal_title：Intensive care medicine

authors： Dehmel C,Braune SA,Kreymann G,Baehr M,Langebrake C,Hilgarth H,Nierhaus A,Dartsch DC,Kluge S

更新日期：2011-08-01 00:00:00

abstract：OBJECTIVE:There are a number of potential etiologies of severe bleeding encountered in the intensive care unit. Although rare, acquired hemophilia is one such etiology that often presents with major bleeding requiring intensive care. Despite the introduction of effective treatments, the reported mortality rate of patie...

journal_title：Intensive care medicine

authors： Shander A,Walsh CE,Cromwell C

更新日期：2011-08-01 00:00:00

abstract：PURPOSE:Hypoxic hepatitis (HH) is a form of hepatic injury following arterial hypoxemia, ischemia, and passive congestion of the liver. We investigated the incidence and the prognostic implications of HH in the medical intensive care unit (ICU). METHODS:A total of 1,066 consecutive ICU admissions at three medical ICUs...

journal_title：Intensive care medicine

authors： Fuhrmann V,Kneidinger N,Herkner H,Heinz G,Nikfardjam M,Bojic A,Schellongowski P,Angermayr B,Schöniger-Hekele M,Madl C,Schenk P

更新日期：2011-08-01 00:00:00

abstract：PURPOSE:To evaluate the diagnostic accuracy of ultrasonography of optic nerve sheath diameter (ONSD) for assessment of intracranial hypertension. METHODS:Systematic review without language restriction based on electronic databases, with manual review of literature and conference proceedings until July 2010. Studies we...

journal_title：Intensive care medicine

authors： Dubourg J,Javouhey E,Geeraerts T,Messerer M,Kassai B

更新日期：2011-07-01 00:00:00

abstract：PURPOSE:Inflammatory markers may have a role in predicting severity of illness of intensive care unit (ICU) patients. The aim of this study is to determine whether low eosinophil count can predict 28-day mortality in medical ICU. METHODS:A prospective study over a 4-month period. To evaluate the prognosis information ...

journal_title：Intensive care medicine

authors： Abidi K,Belayachi J,Derras Y,Khayari ME,Dendane T,Madani N,Khoudri I,Zeggwagh AA,Abouqal R

更新日期：2011-07-01 00:00:00

abstract：PURPOSE:Meconium aspiration syndrome (MAS) is a life-threatening neonatal lung injury, whose pathophysiology has been mainly studied in animal models. In such models, pancreatic secretory phospholipase A2 (sPLA2-IB) and proinflammatory cytokines present in meconium challenge the lungs, catabolising surfactant and harmi...

journal_title：Intensive care medicine

authors： De Luca D,Minucci A,Tripodi D,Piastra M,Pietrini D,Zuppi C,Conti G,Carnielli VP,Capoluongo E

更新日期：2011-07-01 00:00:00

abstract：PURPOSE:The aim of this study is to examine family members' experiences of end-of-life decision-making processes in Norwegian intensive care units (ICUs) to ascertain the degree to which they felt included in the decision-making process and whether they received necessary information. Were they asked about the patient'...

journal_title：Intensive care medicine

authors： Lind R,Lorem GF,Nortvedt P,Hevrøy O

更新日期：2011-07-01 00:00:00

abstract：PURPOSE:We evaluated whether oscillatory compliance (C(X5)) measured by forced oscillation technique (FOT) at 5 Hz may be useful for positive end-expiratory pressure (PEEP) optimisation. METHODS:We studied seven pigs in which lung injury was induced by broncho-alveolar lavage. The animals were ventilated in volume con...

journal_title：Intensive care medicine

authors： Dellacà RL,Zannin E,Kostic P,Olerud MA,Pompilio PP,Hedenstierna G,Pedotti A,Frykholm P

更新日期：2011-06-01 00:00:00

abstract：PURPOSE:An International Consensus Conference proposed classifying weaning into simple, difficult, and prolonged weaning. However, the usefulness of this classification in a respiratory intensive care unit (ICU) is unknown. The aims of the study were: (1) to compare the clinical characteristics and outcomes of patients...

journal_title：Intensive care medicine

authors： Sellares J,Ferrer M,Cano E,Loureiro H,Valencia M,Torres A

更新日期：2011-05-01 00:00:00

abstract：OBJECTIVE:To describe the incidence, risk factors, and impact on mortality of acute kidney injury (AKI) in patients with 2009 influenza A (H1N1) viral pneumonia requiring mechanical ventilation. DESIGN:Observational cohort study. PATIENTS AND METHODS:AKI was defined as risk, injury or failure, according to the RIFLE ...

journal_title：Intensive care medicine

authors： Nin N,Lorente JA,Soto L,Ríos F,Hurtado J,Arancibia F,Ugarte S,Echevarría E,Cardinal P,Saldarini F,Bagnulo H,Cortés I,Bujedo G,Ortega C,Frutos F,Esteban A

更新日期：2011-05-01 00:00:00

abstract：PURPOSE:A retrieval program was developed in New South Wales (NSW), Australia to provide extracorporeal membrane oxygenation support (ECMO) for the safe transport of adults with severe, acute respiratory or cardiac failure. We describe the development and results of this program and the impact of the 2009 H1N1 epidemic...

journal_title：Intensive care medicine

authors： Forrest P,Ratchford J,Burns B,Herkes R,Jackson A,Plunkett B,Torzillo P,Nair P,Granger E,Wilson M,Pye R

更新日期：2011-05-01 00:00:00

abstract：PURPOSE:The intravenous fluid 6% hydroxyethyl starch (130/0.4) (6% HES 130/0.4) is used widely for resuscitation but there is limited information on its efficacy and safety. A large-scale multi-centre randomised controlled trial (CHEST) in critically ill patients is currently underway comparing fluid resuscitation with...

journal_title：Intensive care medicine

authors： Crystalloid versus Hydroxyethyl Starch Trial (CHEST) Management Committee.

更新日期：2011-05-01 00:00:00

abstract：INTRODUCTION:Trials of tight glucose control have compared measures of central tendency, such as average blood glucose, and yielded conflicting results. Other metrics, such as standard deviation, reflect different properties of glucose control and are also associated with changes in outcome. It is possible, therefore, ...

journal_title：Intensive care medicine

authors： Mackenzie IM,Whitehouse T,Nightingale PG

更新日期：2011-03-01 00:00:00

abstract：PURPOSE:To evaluate the efficacy and safety of intravenous sildenafil for immediate postoperative pulmonary hypertension (PH) in pediatric patients undergoing congenital heart surgery. METHODS:A double-blind, multicenter, placebo-controlled, dose-ranging, parallel-group trial was conducted. Patients were randomized to...

journal_title：Intensive care medicine

authors： Fraisse A,Butrous G,Taylor MB,Oakes M,Dilleen M,Wessel DL

更新日期：2011-03-01 00:00:00

abstract：BACKGROUND:Adult studies evaluating corticosteroids have found varied efficacy. One study showing mortality benefit utilized fludrocortisone (FLU) and hydrocortisone (HC) (Effect of treatment with low doses of hydrocortisone and fludrocortisone on mortality in patients with septic shock. JAMA 288:862-871, 2002). Use of...

journal_title：Intensive care medicine

authors： Hebbar KB,Stockwell JA,Fortenberry JD

更新日期：2011-03-01 00:00:00

abstract：:Achievement of a mean blood pressure (MBP) target is one of the hemodynamic goals to ensure an adequate blood perfusion pressure in critically ill patients. Arterial catheter allows for a continuous and precise monitoring of arterial pressure signal. In addition to giving a precise MBP monitoring, analysis of the bloo...

journal_title：Intensive care medicine

authors： Augusto JF,Teboul JL,Radermacher P,Asfar P

更新日期：2011-03-01 00:00:00

abstract：BACKGROUND:Peripherally inserted central venous catheters (PICC) have been proposed as an alternative to central venous catheters (CVC). The aim of this study was to determine the thrombosis rate in relation to PICC placement in patients discharged from the intensive care unit (ICU). METHODS:Data of patients admitted ...

journal_title：Intensive care medicine

authors： Bonizzoli M,Batacchi S,Cianchi G,Zagli G,Lapi F,Tucci V,Martini G,Di Valvasone S,Peris A

更新日期：2011-02-01 00:00:00

abstract：OBJECTIVES:Diagnosing persistent acute kidney injury (AKI) as opposed to transient AKI in critically ill patients may help physicians in making treatment decisions. This diagnosis relies chiefly on urinary indices, which may be of limited value or difficult to obtain. We assessed the performance of the Doppler renal re...

journal_title：Intensive care medicine

authors： Darmon M,Schortgen F,Vargas F,Liazydi A,Schlemmer B,Brun-Buisson C,Brochard L

更新日期：2011-01-01 00:00:00

abstract：PURPOSE:Extracorporeal membrane oxygenation (ECMO) can support oxygenation and carbon dioxide elimination in severe lung failure. Usually it is accompanied by controlled mechanical ventilation. Neurally adjusted ventilatory assist (NAVA) is a new mode of ventilation triggered by the diaphragmatic electrical activity an...

journal_title：Intensive care medicine

authors： Karagiannidis C,Lubnow M,Philipp A,Riegger GA,Schmid C,Pfeifer M,Mueller T

更新日期：2010-12-01 00:00:00

abstract：PURPOSE:To assess the feasibility of remifentanil-based sedation in hypoxemic acute respiratory failure (HARF) patients refusing to continue noninvasive ventilation (NPPV) for intolerance to two different interfaces-helmet and total face mask. DESIGN AND SETTING:Prospective uncontrolled clinical investigation in a 14-...

journal_title：Intensive care medicine

authors： Rocco M,Conti G,Alessandri E,Morelli A,Spadetta G,Laderchi A,Di Santo C,Francavilla S,Pietropaoli P

更新日期：2010-12-01 00:00:00

abstract：PURPOSE:To examine the consequences of administration of norepinephrine on muscle tissue oxygenation in severely hypotensive septic shock patients. METHODS:This was a prospective observational study conducted in a medical intensive care unit of a university hospital. We included 28 septic shock patients that received ...

journal_title：Intensive care medicine

authors： Georger JF,Hamzaoui O,Chaari A,Maizel J,Richard C,Teboul JL

更新日期：2010-11-01 00:00:00

abstract：PURPOSE:To determine whether, during mechanical ventilation, an optimal positive end-expiratory pressure (PEEP) can be identified by measurement of regional tidal volume and compliance [V (T(reg)), C (RS(reg))]. METHODS:Sixteen anaesthetized intubated neonatal piglets underwent a stepwise vital capacity manoeuvre perf...

journal_title：Intensive care medicine

authors： Dargaville PA,Rimensberger PC,Frerichs I

更新日期：2010-11-01 00:00:00

abstract：PURPOSE:To compare characteristics, clinical evolution and outcome in adult patients with influenza A (H1N1) acute respiratory distress syndrome (ARDS) treated with or without extracorporeal membrane oxygenation (ECMO). METHODS:A prospective observational study of patients treated in Marseille South Hospital from Octo...

journal_title：Intensive care medicine

authors： Roch A,Lepaul-Ercole R,Grisoli D,Bessereau J,Brissy O,Castanier M,Dizier S,Forel JM,Guervilly C,Gariboldi V,Collart F,Michelet P,Perrin G,Charrel R,Papazian L

更新日期：2010-11-01 00:00:00

abstract：PURPOSE:The early diagnosis of traumatic internal carotid artery dissection (TICAD) is essential for initiating appropriate treatment and improving outcome. We searched for criteria from transcranial Doppler (TCD) measurements on admission that could be associated with subsequent TICAD diagnosis in patients with trauma...

journal_title：Intensive care medicine

authors： Bouzat P,Francony G,Brun J,Lavagne P,Picard J,Broux C,Declety P,Jacquot C,Albaladejo P,Payen JF

更新日期：2010-09-01 00:00:00

abstract：PURPOSE:Computerized clinical decision support systems (CDSS) for intensive insulin therapy (IIT) generate recommendations using blood glucose (BG) values manually transcribed from testing devices to computers, a potential source of error. We quantified the frequency and effect of blood glucose transcription mismatches...

journal_title：Intensive care medicine

authors： Campion TR Jr,May AK,Waitman LR,Ozdas A,Gadd CS

更新日期：2010-09-01 00:00:00

abstract：INTRODUCTION:Most anxiolytics and sedative regimens in the intensive care unit (ICU) impair intellectual function, reducing patient autonomy, and often add to patient morbidity. Using an ICU-validated cognitive assessment tool Adapted Cognitive Exam (ACE), we performed a comparison between dexmedetomidine (DEX) and pro...

journal_title：Intensive care medicine

authors： Mirski MA,Lewin JJ 3rd,Ledroux S,Thompson C,Murakami P,Zink EK,Griswold M

更新日期：2010-09-01 00:00:00

abstract：PURPOSE:Hypoxia-ischemia (HI), as a major cause of fetal brain damage, has long-lasting neurological implications. Therefore, therapeutic interventions that attenuate the neuropathological outcome of HI while also improving the neurofunctional outcome are of paramount clinical importance. The aim of this study was to i...

journal_title：Intensive care medicine

authors： Fathali N,Lekic T,Zhang JH,Tang J

更新日期：2010-09-01 00:00:00